The downsides of massiveness
If you're not used to big and/or multiple displays, you may find the required head movements tiring. For me, though, I'm doing much less moving about, as my pixels are now much closer together horizontally. The Seiki comes on a fixed stand; you can't adjust tilt or swivel without pivoting the entire set. I found the fixed angle fine on my desk, but a wall mount would provide more flexibility.
Big screens do make it easy to lose the cursor, however; you'll probably want to use a tool like Mouseposé or similar that lets you call out the cursor's location via a hot key. I regularly lose track of where my cursor is hiding amongst all those pixels.
And while we're on mouse-related items, a big screen requires lots of cursor movement: Getting from one side to the other takes about three swipes of my trackpad. This can get tiring after a while; I find myself using keyboard shortcuts whenever I can, as well as switching directly to the window I wish to access, either via the Dock's contextual menus or via our own window switching utility, Witch.
The last word
Super-large monitors aren't for everyone--honestly, I'm not sure this one's for me yet. I've been using it for several weeks, and while I like it a lot, it does take up a lot of my desk (both horizontally and vertically). But for the price, if you've got a Mac that can use it and need for more screen real estate, it's a relatively cheap way to add a massive amount of pixels to your setup.
Sign up for CIO Asia eNewsletters.