I think Cities: Skylines will be good, but it's hard to say. All we've done is play the early-game so far, and if you'll remember back to two years ago it wasn't until late in the game that SimCity's biggest problems became apparent.
Skylines is doing some things right though: Massive areas to build in, plenty of transportation options, and some interesting secondary simulations (traffic, water, wind, et cetera). Plus mod support both official and unofficial — did I mention that infinite money "cheat" is built into the game for when you want a more relaxing/creative session?
The UI could use some simplification and the tutorials are a bit wacky at times, but overall I'm happy about my time with the game. We'll have an official (and extensive) review once the game's out in March.
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