Dual-GPU solutions require compromise. For one thing, they suck up a ton of case space — two full-length cards in the case of a pair of GeForce 980s in SLI, and a long, heavy card with a sizeable water cooling setup if you go with AMD's flagship 295x2. Drivers and optimizations for multi-GPU setups also tend to be slower to appear and much more finicky, as evidenced by the Shadow of Mordor wonkiness with the 295x2. (Nvidia has had an initiative to have SLI support on the day of launch for top titles but the lower-tier games don't get the same commitment.)
Likewise, single-GPU graphics cards can also fit in tighter spaces than multi-GPU solutions. You could, for example, squeeze the Titan X into a relatively small form factor PC, which would be downright impossible with the Radeon 295x2 or dual 980s. Dual-GPU solutions consume more power and tend to spit out more waste heat than single cards, too.
Because of all that, our standard recommendation is to rock the most powerful single-GPU graphics card you can buy. If you're looking for pure, unadulterated, price-is-no-concern single-GPU power, that card is clearly the Titan X, and the 12GB frame buffer helps guarantee the card will continue to be relevant as we move deeper into the 4K resolution era. Hail to the new GPU king, baby — though AMD has a new generation of Radeon cards barreling down the pipeline soon.
And if you're made of cash and aren't scared of running multiple graphics cards, can you imagine how potent two Titan Xs in SLI would be? I'm quivering just thinking about it....
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