Asked to comment on his remarks, Blank said, "There is an evolution on what is patentable and what isn't. Obviously, that's going to continue."
Blank will spend part of Wednesday speaking to inventors and tinkerers at TechShop, a kind of geek's gym where a monthly membership buys access to a variety of complex electronic and mechanical machinery.
Speaking to local and state officials, she lauded Silicon Valley's culture of innovation, which makes the region responsible for one in 10 of all U.S. patents.
"The ideas and the products that flow out of Silicon Valley not only help businesses here, but help all of America's businesses to grow and to create jobs," she said.
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