NEW YORK -- Sixty years from now, we'll look back on today's 3D-printed tissue and organ technology and think it's as primitive as the iron lung seems to us now.
Six decades out, replacing a liver or a kidney will likely be a routine procedure that involves harvesting some patients cells, growing them and then printing them across artificial scaffolding.
Dr. Anthony Atala, director of the Wake Forest Institute for Regenerative Medicine, spoke at the Inside 3D Printing Conference here about where the technology is today, and what hurdles it still must overcome.
The biggest hurdle is being able to 3D print supportive vascular structure so that tissue can receive the oxygen critical to its survival once it's implanted into a patient.
Today, scientists can replicate tissue in small amounts beginning with the simplest: flat human skin tissue. Researchers have been able to create tubular blood vessels, and even parts of hollow organs of the body, such as the bladder. But, it's the solid, hard organs, such as the liver and the kidney, that are more complex and require far more vascular support to recreate successfully.
"We're working very hard to make sure we get there someday," Atala said.
It's not as insurmountable a goal as it may seem. For one, scientists don't need to replicate an entire organ. In fact, up to 90% of an organ can fail before it seriously affects the health of a patient, Atala said.
"Imagine you're playing tennis one weekend and you get chest pains. You go and get an x-ray and they find 90% of you're your heart vessel is occluded. The fact is you never had chest pain when your heart vessel was 80% occluded," he said. "It's the same thing with kidneys. You don't get into kidney failure until about 90% of your kidney is gone. So you have to burn 90% of your reserve before you get in trouble."
The current strategy of bioengineers is to create enough tissue to boost an organ that's failing while not completely replacing it, Atala said
Typically, the maximum distance between tissue and the vascular structures that support them is 3mm. That means that for every 3mm of tissue, physicians will have to be able to construct capillaries to support them.
Today, 3D bioprinting constructs a series of tissue held up by artificial scaffolding, like the iron beams in a building. First a layer of scaffolding is laid down, and then a layer of cells is laid down on top of that.
In the past, scientists have had to separately create the scaffolding, and then coat it with the living cells. That not only takes longer to complete, but it also places the living cells in danger of dying before they can even be implanted.
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