Several OS X Twitter clients let you view multiple lists in columns. If you want to follow more than one list live, this is both practical and handy. For example, if you have a list for friends, and another for work, you may want to keep both visible. Twitter's free TweetDeck and Tweetbot both offer multiple-column views, as do some other clients.
So if you need to wrangle your Twitter feed, try using lists. You can split up the accounts you follow by category, and not be overwhelmed by too many tweets in your timeline. It takes a while to set up, but you may find that it makes your life on Twitter a bit easier.
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