Gaming on several displays at once requires far more graphical firepower than gaming on a single screen alone, because the GPU has so many more pixels to push--so if you are not running multiple graphics cards in a SLI or Crossfire setup, you will almost certainly see lag and artifacting in your multi-monitor games. Quite simply, a single graphics card usually does not have the power to run multiple high-resolution, high-intensity displays at once (although some do--check out our graphics card showdown).
Before you can start playing your games across multiple panels, you will need to set up your graphics card and your game. Nvidia users will need to set up Nvidia Surround, while AMD users will need to create an Eyefinity group for their monitors.
You will also need to go into your game--not all games are multi-monitor compatible--and configure the video or display settings to the correct resolution so that the game spans across all of your monitors instead of staying squished on just one. You will also want to play around with other settings as the game allows, including field of view (too low, and there will be too much going on around you; too high and everything on your left and right screens will be hugely distorted).
For gaming, it is easier if you have multiple identical displays, because otherwise you will run into issues with resolution, distortion (if your displays are not at the same height), and color calibration, all of which can be difficult to work with if you are trying to play in a "seamless" environment.
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