Sure, there will still be some programs that demand powerful local resources, such as Adobe Photoshop, Apple Final Cut Pro and massively multiplayer online role-playing games that require a PC. But for most users (I'm going to put the figure at 95%), nearly all of their applications (99% doesn't seem unreasonable) will run off the cloud, and that is where users will store their data as well. What OS will they use to get to the cloud? Whatever.
As long as they can get to the apps they want, users couldn't care less.
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